ARUP's Laboratory Test Directory

N-myc by FISH : 0049235

Mnemonic: NMYC

Methodology: Fluorescence in situ Hybridization
Performed: Weekly
Reported: 4-12 days
Specimen Required: Collect:  Tumor tissue.

Transport:  Paraffin-embedded, formalin-fixed tissue block at 20-25°C. Protect paraffin block from excessive heat.  Ship in cooled container during summer months. Include surgical pathology report.

Remarks:  Only tissue that is clearly carcinoma (established by histopathologic criteria) should be tested.

Unacceptable Conditions:  No tumor in tissue. Specimens fixed/processed in alternative fixatives (alcohol, Prefer®) .

Stability:  Ambient: Indefinitely; Refrigerated: Acceptable; Frozen: Unacceptable
Reference Interval:
Amplified: N-myc/CEP2 ratio: Greater than or equal to 2.0
Non-amplified: N-myc/CEP2 ratio: Less than 2.0
Interpretive Data: A result of "non-amplified" for the N-myc proto-oncogene suggests a favorable prognosis.  An amplified result is considered a poor prognostic indicator and is associated with decreased disease-free survival and overall survival.

Current literature suggests this gene is of prognostic value for the evaluation of neuroblastoma and medulloblastoma.

Please refer to Statement A in the Compliance Statements section in the front of the Laboratory Test Directory.
CPT Code(s): 88368 x2
 
 

 

 

 
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