ARUP's Laboratory Test Directory
| 0049235: N-myc by FISH |
| Test Mnemonic: NMYC | |
|
Methodology: Fluorescence in situ Hybridization
Performed: Weekly Reported: 4-12 days |
| Specimen Required: | |
|
Collect: Tumor tissue.
Transport: Paraffin-embedded, formalin-fixed tissue block at 20-25°C. Protect paraffin block from excessive heat. Ship in cooled container during summer months. Include surgical pathology report. Remarks: Only tissue that is clearly carcinoma (established by histopathologic criteria) should be tested. Unacceptable Conditions: No tumor in tissue. Specimens fixed/processed in alternative fixatives (alcohol, Prefer®) . Stability: Ambient: Indefinitely; Refrigerated: Acceptable; Frozen: Unacceptable |
|
| Reference Interval: |
|
Amplified: N-myc/CEP2 ratio: Greater than or equal to 2.0 Non-amplified: N-myc/CEP2 ratio: Less than 2.0 |
| Interpretive Data: | |
|
A result of "non-amplified" for the N-myc proto-oncogene suggests a favorable prognosis. An amplified result is considered a poor prognostic indicator and is associated with decreased disease-free survival and overall survival. Current literature suggests this gene is of prognostic value for the evaluation of neuroblastoma and medulloblastoma. Please refer to Statement A in the Compliance Statements section in the front of the Laboratory Test Directory. |
| CPT Code(s): | |
| 88368 x2 |