EGFR Gene Amplification by FISH

ARUP's Laboratory Test Directory

EGFR Gene Amplification by FISH : 0049234

Mnemonic: EGFRFISH

Methodology:	Fluorescence in situ Hybridization
Performed:	Varies
Reported:	4-12 days
Specimen Required:	Collect: Tumor tissue. Specimen Preparation: Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Transport tissue block or 6 unstained 5 micron slides. (Min: 3 slides) Protect paraffin block from excessive heat. Transport block(s) and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. Storage/Transport Temperature: Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months. Remarks: Include surgical pathology report. Unacceptable Conditions: Frozen specimens. Specimens fixed or processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens. Stability (collection to initiation of testing): Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval:

Test Number	Components	Reference Interval
	EGFR by FISH	Nonamplified: LSI EGFR:CEP7 Less than 2.0 Amplified: LSI EGFR:CEP7 Greater than or equal to 2.0
	EGFR:CEP7	By report
	EGFR per Cells Counted Ratio	By report

Interpretive Data:

Refer to report.

See Compliance Statement A: www.aruplab.com/CS

CPT Code(s):

88368 x2

Cross References:

Her-1 (EGFR Gene Amplification by FISH)

Testing Information