ARUP's Laboratory Test Directory

0049234: EGFR by FISH

Test Mnemonic: EGFRFISH
Methodology: Fluorescence in situ Hybridization

Performed: Weekly

Reported: 4-12 days

Specimen Required:  
Collect: Tumor tissue.

Transport: One paraffin-embedded, formalin-fixed tissue block at 20-25°C.  Protect paraffin bloc from excessive heat.  Ship in cooled container during summer months.  Include surgical pathology report.

Remarks: Only tissue that is clearly carcinoma (established by histopathologic criteria) should be tested.

Unacceptable Conditions: Samples fixed/processed in alternate fixatives (alcohol, Prefer®, etc.) should not be submitted.  No tumor in tissue or frozen tissue.

Stability: Paraffin block: Ambient: Indefinitely; Refrigerated: Acceptable; Frozen: Unacceptable

Reference Interval:
 
Test Number Components Reference Interval
 EGFR by FISH Nonamplified: LSI EGFR:CEP7 Less than 2.0
Amplified: LSI EGFR:CEP7 Greater than or equal to 2.0
 EGFR:CEP7 By report
 EGFR per Cells Counted Ratio By report

CPT Code(s):
88368 x2