ARUP's Laboratory Test Directory

IgVH Mutation Analysis by Sequencing : 0040227
[ image for: Time Sensitive]
Time Sensitive
  


Mnemonic: IGVH MUT

Methodology: Polymerase Chain Reaction/Sequencing
Performed: Varies
Reported: 12-14 days
Specimen Required: Collect: Lavender (EDTA) or bone marrow (EDTA).

Specimen Preparation: Transport 5 mL whole blood OR 3 mL bone marrow. (Min: 1 mL whole blood OR 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA..

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Serum or plasma. Specimens collected in preservatives other than EDTA. Frozen specimens. Clotted or severely hemolyzed specimens.

Stability (collection to initiation of testing): Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable

Interpretive Data: Refer to report.

Refer to Statement B under Testing Information at http://www.aruplab.com.
Note: This assay is designed for individuals with a confirmed diagnosis of CLL, and for these individuals testing will include sequencing.  All other diagnoses will terminate after amplification and will not have the sequencing component.
CPT Code(s): 83891 Isolation; 83902 Reverse transcription; 83898 x5 Amplification; 83894 Gel separation;  83912 Interpretation and report; if sequencing is performed, add 83892 Enzyme digestion;  83904 Sequencing, 83909 Capillary electrophoresis - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
Cross References: IgVH Somatic Hypermutation (IgVH Mutation Analysis by Sequencing)
 
 

 

 

 
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