ARUP's Laboratory Test Directory

IGHV Mutation Analysis by Sequencing : 0040227
[ image for: Time Sensitive]
Time Sensitive
[ image for: Additional Technical Information]
Additional Technical Information


Mnemonic: IGHV MUT

Methodology: Polymerase Chain Reaction/Sequencing
Performed: Varies
Reported: 12-14 days
Specimen Required: Collect: Lavender (EDTA) or bone marrow (EDTA).

Specimen Preparation: Transport 5 mL whole blood OR 3 mL bone marrow. (Min: 1 mL whole blood OR 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA..

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Serum or plasma. Frozen or clotted specimens. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed specimens.

Stability (collection to initiation of testing): Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable
Interpretive Data: Refer to report.

See Compliance Statement B: www.aruplab.com/CS
Note: This assay is designed for individuals with a confirmed diagnosis of CLL, and for these individuals testing will include sequencing.  All other diagnoses will terminate after amplification and will not have the sequencing component.
CPT Code(s): 81263, G0452
Cross References: IgVH Somatic Hypermutation (IgVH Mutation Analysis by Sequencing)