ARUP's Laboratory Test Directory

Thrombotic Risk (Acquired) Reflexive Panel : 0030268

Mnemonic: HYPERCOAG

Methodology: Refer to individual components
Performed: Refer to individual components
Reported: 1-8 days
Specimen Required: Collect: Lt. blue (sodium citrate) for lupus and d-dimer. AND serum separator tube for cardiolipin. AND serum separator tube OR green (sodium or lithium heparin) for homocysteine.

Specimen Preparation: Transfer two 2 mL aliquots of platelet-poor plasma. AND 2 mL serum. AND 1 mL plasma to individual ARUP Standard Transport Tubes.

Storage/Transport Temperature: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions: Refer to individual components.

Stability (collection to initiation of testing): Refer to individual components.
Reference Interval:
 
Test Number Components Reference Interval
 Prothrombin Time 12.0-15.5 seconds
 Partial Thromboplastin Time 32-48 seconds
 Dilute Russell Viper Venom Time (dRVVT) 33-44 seconds
0050901Cardiolipin Antibody, IgG 0-14 GPL: Negative
15-19 GPL: Indeterminate
20-80 GPL: Low to Medium positive
81 GPL or above: High positive
0050902Cardiolipin Antibody, IgM 0-12 MPL: Negative
13-19 MPL: Indeterminate
20-80 MPL: Low to Medium Positive
81 MPL or above: High positive
0030057D-Dimer 0.0-0.4 µg/mL
0099869Homocysteine, Total < 11 µmol/L, for both male and female
 Thrombin Time 14.7-19.5 seconds
 Reptilase Time Less than 22.0 seconds
 PTT Heparin Neutralized 32-48 seconds
 Partial Thromboplastin Time 1:1 Mix (performed if PTT > 48 seconds) 32-48 seconds
 Platelet Neutralization Procedure (performed if PTT 1:1 Mix > 48 seconds) Negative
 Dilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT > 44 seconds) 33-44 seconds
 Dilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix > 44 seconds) Negative
 Hexagonal Phospholipid Neutralization Negative

Interpretive Data: Refer to report.
Note: If PTT is elevated, then PTT 1:1 mix will be added. If PTT 1:1 mix is elevated, then platelet neutralization test will be added.  If dRVVT is elevated, then dRVVT 1:1 mix will be added. If the dRVVT 1:1 mix is elevated, then the dRVVT confirmation test will be added.  Additional charges apply.
CPT Code(s): 85610 PT-D; 85730 PTT-D; 85613 dRVVT; 86147 X2 Cardiolipin G/M; 85379 D-dimer; 83090 Homocysteine.  If PTT is abnormal, add 85670 Thrombin Time.  If Thrombin time is abnormal, add 85635 Reptilase Time.  If Reptilase Time is normal, add PTT Heparin Neutralization 85730 and 85525.  If PTT Heparin Neutralization is abnormal, add 85732 PTT 1:1 mix.  If PTT 1:1 mix is abnormal, add 85597 Platelet neutralization procedure (PNP).  If dRVVT is abnormal, add 85613 dRVVT 1:1 mix.  If dRVVT 1:1 mix is abnormal, perform 85613 dRVVT confirmation.  If PNP and dRVVT conf are normal, add 85598 Hexagonal Phospholipid Neutralization.
Cross References: Hypercoag (Thrombotic Risk (Acquired) Reflexive Panel), Hypercoagulable Panel (Acquired) Reflexive Panel, Thrombophilia (Thrombotic Risk (Acquired) Reflexive Panel)
 
 

 

 

 
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