ARUP's Laboratory Test Directory

Thrombotic Risk (Acquired) Reflexive Panel : 0030268

Mnemonic: HYPERCOAG

Ordering Recommendation: Acceptable screening panel for acquired thrombophilia.
Methodology: Electromagnetic Clot Detection/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Immunoturbidimetry/Quantitative Enzymatic
Performed: Refer to individual components
Reported: 1-8 days
Specimen Required: Collect: Lt. blue (sodium citrate) for lupus and d-dimer. AND serum separator tube for cardiolipin. AND serum separator tube OR green (sodium or lithium heparin) for homocysteine.

Specimen Preparation: Transfer two 2 mL aliquots of platelet-poor plasma. AND 2 mL serum. AND 1 mL plasma to individual ARUP Standard Transport Tubes.

Storage/Transport Temperature: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions: Refer to individual components.

Stability (collection to initiation of testing): Refer to individual components.
Reference Interval:
 
Test Number Components Reference Interval
 Prothrombin Time 12.0-15.5 seconds
 Partial Thromboplastin Time 32-48 seconds
 Dilute Russell Viper Venom Time (dRVVT) 33-44 seconds
0050901Cardiolipin Antibody, IgG 0-14 GPL: Negative
15-19 GPL: Indeterminate
20-80 GPL: Low to Medium positive
81 GPL or above: High positive
0050902Cardiolipin Antibody, IgM 0-12 MPL: Negative
13-19 MPL: Indeterminate
20-80 MPL: Low to Medium Positive
81 MPL or above: High positive
0030057D-Dimer 0.0-0.4 µg/mL
0099869Homocysteine, Total < 11 µmol/L, for both male and female
 Thrombin Time 14.7-19.5 seconds
 Reptilase Time Less than 22.0 seconds
 PTT Heparin Neutralized 32-48 seconds
 Partial Thromboplastin Time 1:1 Mix (performed if PTT > 48 seconds) 32-48 seconds
 Platelet Neutralization Procedure (performed if PTT 1:1 Mix > 48 seconds) Negative
 Dilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT > 44 seconds) 33-44 seconds
 Dilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix > 44 seconds) Negative
 Hexagonal Phospholipid Neutralization Negative

Interpretive Data: Refer to report.
Note: If PTT is elevated, then PTT 1:1 mix will be added. If PTT 1:1 mix is elevated, then platelet neutralization test will be added.  If dRVVT is elevated, then dRVVT 1:1 mix will be added. If the dRVVT 1:1 mix is elevated, then the dRVVT confirmation test will be added.  Additional charges apply.
CPT Code(s): 85610; 85730; 85613; 86147 x2; 85379; 83090; if reflexed, add 85670;  if reflexed, add 85635; if normal, add 85730 and 85525; if abnormal, add 85732; if abnormal, add 85597; if abnormal, add 85613; if abnormal, add 85613; if normal, add 85598
Cross References: Hypercoag (Thrombotic Risk (Acquired) Reflexive Panel), Hypercoagulable Panel (Acquired) Reflexive Panel, Thrombophilia (Thrombotic Risk (Acquired) Reflexive Panel)