ARUP's Laboratory Test Directory

0030181: Lupus Anticoagulant Reflexive Panel

Test Mnemonic: LUPUS R
Methodology: Clotting

Performed: Sun-Sat

Reported: 1-2 days

Specimen Required:  
Collect: One 5 mL lt. blue (sodium citrate).  Refer to the Hemostasis/Thrombosis Specimens section in the front of this User's Guide for specimen collection instructions.

Transport: 2 mL platelet-poor plasma, frozen. (Min: 1.5 mL) Submit specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 1 mL platelet-poor plasma, frozen.

Remarks: CRITICAL FROZEN.

Unacceptable Conditions: Serum and nonsodium citrate plasma.

Stability: Ambient: 4 hours; Refrigerated: 24 hours; Frozen: 1 week

Reference Interval:
 
Test Number Components Reference Interval
 Prothrombin Time 12.0-15.5 seconds
0030232Partial Thromboplastin Time 32-48 seconds
 Dilute Russell Viper Venom Time (dRVVT) 33-44 seconds
 Thrombin Time 14.7-19.5 seconds
 Reptilase Time Less than 22.0 seconds
 PTT Heparin Neutralized 32-48 seconds
 Partial Thromboplastin Time 1:1 Mix (performed if PTT > 48 seconds) 32-48 seconds
 Platelet Neutralization Procedure (performed if PTT 1:1 Mix > 48 seconds) 0.0-7.0 seconds
 Dilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT > 44 seconds) 33-44 seconds
 Dilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix > 44 seconds) Less than 1.34
 Hexagonal Phospholipid Neutralization Negative

Interpretive Data:




Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

Please refer to Statement C in the Compliance Statements section in the front of the Laboratory Test Directory.



Note:
If PTT and dRVVT are normal, then no further testing is performed. If PTT is abnormal, Thrombin Time is added. If Thrombin Time is normal, PTT 1:1 mix is added.  If Thrombin time is abnormal, Reptilase Time is added. If Reptilase time is abnormal, PTT 1:1 mix is added. If Reptilase Time is normal, PTT Heparin Neutralization is added. If PTT Heparin Neutralization is abnormal, PTT 1:1 mix is added.  If PTT 1:1 mix is abnormal, Platelet Neutralization procedure is added. If dRVVT is abnormal, dRVVT 1:1 mix is added. If dRVVT 1:1 mix is abnormal, dRVVT confirmation is added. If Platelet Neutralization procedure and dRVVT confirmation are normal or if one is normal and the other not done, Hexagonal Phospholipid Neutralization is added. Additional charges may apply.

CPT Code(s):
85610 Prothrombin time (PT); 85730 Partial Thromboplastin Time (PTT); 85613 dRVVT. If PTT is abnormal, add 85670 Thrombin Time. If Thrombin time is abnormal, add 85635 Reptilase Time. If Reptilase Time is normal, add PTT Heparin Neutralization 85730 and 85525. If PTT Heparin Neutralization is abnormal, add 85732 PTT 1:1 mix. If PTT 1:1 mix is abnormal, add 85597 Platelet neutralization procedure (PNP). If dRVVT is abnormal, add 85613 dRVVT 1:1 mix. If dRVVT 1:1 mix is abnormal, perform 85613 dRVVT confirmation. If PNP and dRVVT conf are normal, add 85597 Hexagonal Phospholipid Neutralization.

 

 

 
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