ARUP's Laboratory Test Directory

Protein S, Total Antigen : 0030112

Mnemonic: PROT S

Ordering Recommendation: Not recommended for detecting protein S deficiency; preferred test is Protein S Free, Antigen (0098894). Use to subtype deficiency in known protein S-deficient individuals in combination with Protein S Free, Antigen (0098894), or Protein S, Functional (0030114). Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Methodology: Microlatex Particle-Mediated Immunoassay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation: Transfer 1.5 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions: Serum. Non-frozen or hemolyzed specimens.

Stability (collection to initiation of testing): Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval:
1-4 days: 12-60%
5-29 days: 22-78%
30-89 days: 33-93%
90-179 days: 54-118%
180-364 days: 55-119%
1-5 years: 54-118%
6-10 years: 41-114%
11 years and older: Females: 63-126%; Males: 84-134%
Interpretive Data: Patients on warfarin may have decreased protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein S.
CPT Code(s): 85305