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ADAMTS13 Activity
Ordering Recommendation
Assist in diagnosing acquired (idiopathic) or inherited thrombotic thrombocytopenic purpura (TTP).
New York DOH Approval Status
Specimen Required
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 1 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum, EDTA plasma, clotted or hemolyzed specimens.
Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks
Methodology
Chromogenic Assay
Performed
Sun-Sat
Reported
1-3 days
Reference Interval
Effective November 17, 2014
Greater than 60 percent
Interpretive Data
ADAMTS13 levels of less than 10 percent may be associated with either inherited (Upshaw-Schulman Syndrome) or acquired thrombotic thrombocytopenic purpura (TTP).
A variety of medical conditions may result in a mild to moderate deficiency of ADAMTS13 activity. Recent plasma exchange therapy may raise the observed ADAMTS13 activity.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
85397
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0030049 | ADAMTS13 Activity | 53622-7 |
Aliases
- von Willebrand Factor Cleaving Protease
