ARUP's Laboratory Test Directory

Copper, Liver : 0020694

Mnemonic: CU-LIVER

Methodology: Inductively Coupled Plasma/Mass Spectrometry
Performed: Mon, Wed, Fri
Reported: 2-6 days
Specimen Required: Collect:  Liver tissue. .

Transport:  At least a 1 cm long specimen (obtained with an 18 gauge needle) at 2-8°C. Tissue can be fresh, paraffin-embedded, formalin-fixed, or dried.  Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).

Remarks:  Formalin is acceptable, but not preferred.

Unacceptable Conditions:  Specimens less than 0.25 mg (dry weight) and paraffin blocks that have been processed with Hollande's or other copper-containing stain.

Stability:  In paraffin block, preserved (formalin), or dried: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Fresh tissue: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely

Reference Interval:
15-55 µg/g of tissue.
Interpretive Data: Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.
CPT Code(s): 82525
 
 

 

 

 
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