Skip to main content
Ryan A. Metcalf, MD, CQA(ASQ)
Section Chief: Transfusion Medicine
Medical Director: Blood Bank
Inpatient Chief Value Officer, Department of Pathology
University of Utah Health and ARUP Laboratories
Associate Professor (Clinical), University of Utah School of Medicine
Specialties
Transfusion medicine
Clinical pathology
Education
Medical Degree—University of California Davis School of Medicine
Residency—Anatomic and Clinical Pathology, Stanford University School of Medicine
Fellowship—Pathology, Stanford University School of Medicine
Fellowship—Transfusion Medicine, Stanford University School of Medicine
Certification/Affiliations
American Board of Pathology (Blood Bank/Transfusion Medicine, Anatomic and Clinical Pathology)
Research Interests
Data-driven clinical transfusion medicine
Innovation and data visualization of patient blood management practice performance
Artificial intelligence in medicine
Patient blood management
Quality management
Risk quantitation of transfusion-related adverse events
Awards
The William Roberts Award for Excellence in Laboratory Medicine, 2023, Department of Pathology, University of Utah
Outstanding Teaching Award in Clinical Pathology, 2020, Department of Pathology, University of Utah
Recent Publications
Carson JL, et al. Red blood cell transfusion: 2023 AABB international guidelines . JAMA . 2023;330(19):1892–902.
Li N, et al. Blood demand forecasting and supply management: an analytical assessment of key studies utilizing novel computational techniques . Transfus Med Rev . 2023;37(4):150768.
White SK, et al. The incidence of transfusion related acute lung injury using active surveillance: A systematic review and meta-analysis . Transfusion . 2023. [Published online ahead of print Dec 2023]
Walker BS, et al. Meta-analysis of bacterial growth characteristics in platelet components: refining the inputs of a simulation analysis comparing the relative safety of testing strategies . Transfusion . 2023;63(9):1719–27.
Metcalf RA, et al. Current advances in 2022: a critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee . Transfusion . 2023;63(8):1590–600.
Karafin MS, et al. Antibody titers in transfusion medicine: a critical reevaluation of testing accuracy, reliability, and clinical use . Arch Pathol Lab Med . 2023;147(12):1351–9.
Walker BS, et al. Bacterial culture time to detection in platelet components: an evidence synthesis and estimation of detection failures . Transfusion . 2023;63(1):182–92.
White SK, et al. The epidemiology of transfusion-related acute lung injury: a scoping review and analysis . Transfusion . 2023;63(1):104–16.
Potter S, et al. Life threatening platelet transfusion refractoriness due to an anamnestic human leukocyte antigen alloantibody response . Transfusion . 2022;62(11):2161–2.
Estcourt LJ, et al. Clinical practice guidelines from the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 convalescent plasma . Ann Intern Med . 2022;175(9):1310–21.
Metcalf RA, et al. Current advances in transfusion medicine 2021: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee . Transfusion . 2022;62(7):1435–45.
Bloch EM, et al. How do I implement an outpatient program for the administration of convalescent plasma for COVID-19? Transfusion . 2022;62(5):933–41.
Wang Z, et al. Development and validation of a machine learning method to predict intraoperative red blood cell transfusions in cardiothoracic surgery . Sci Rep . 2022;12(1):1355.
Fennell K, et al. New ABO intron 1 variant alleles . Immunohematology . 2021;37(4):178–84.
Benson AE, et al. Transfusion preparedness on labor and delivery: an initiative to improve safety and cost . Obstet Gynecol . 2021;138(5):788–94.
Allen ES, et al. Current advances in transfusion medicine 2020: a critical review of selected topics by the AABB Clinical Transfusion Medicine Committee . Transfusion . 2021;61(9):2756–67.
Lin H, et al. Sanguine: Visual analysis for patient blood management . Information Visualization , 2021;20(2-3):123–37.
Corean J, et al. Platelet component false positive detection rate in aerobic and anaerobic primary culture: a systematic review and meta-analysis. Transfus Med Rev . 2021;35(3):44–52.
Moore RA, et al. In reply: window periods for secondary bacterial culture of platelets according to FDA Guidance . Transfusion . 2021;61(4):1343-4.
Karafin MS, et al. Heterogeneity in approaches for switching from universal to patient ABO type-specific blood components during massive hemorrhage: an international survey and review of the literature . Arch Pathol Lab Med . 2021;145(12):1499–504.
Self WH, et al. Passive immunity trial for our nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. Trials . 2021;22(1):221.
Silva O, et al. Classic Hodgkin lymphoma in Guatemalan children of age less than six years: analysis of immune regulatory pathways and the tumor microenvironment . Leuk Lymphoma . 2021;62(7):1609–18.
Cohn CS, et al. COVID-19 convalescent plasma: interim recommendations from the AABB . Transfusion . 2021;61(4):1313–23.
Metcalf RA, et al. Electronic clinical decision support: evidence that default settings influence end user behavior. Transfusion . 2021;61(3):669-70.
Moore RA, et al. The impact of the sample time of secondary bacterial culture on the risk of exposure to contaminated platelet components: a mathematical analysis . Transfusion . 2021;61(3):873–82.
Luetkens T, et al. Successful transfer of anti-SARS-CoV-2 immunity using convalescent plasma in a multiple myeloma patient with hypogammaglobulinemia and COVID-19 . Blood Adv . 2020;4(19):4864–8.
Corean J, et al. The incremental benefit of anaerobic culture for controlling bacterial risk in platelets: a systematic review and meta-analysis . Vox Sang . 2021;116(4):397–404.
Walker BS, et al. Residual bacterial detection rates following primary culture as determined by secondary culture and rapid testing in platelet components: a systematic review and meta-analysis . Transfusion . 2020;60(9):2029–37.
Walker BS, et al. The comparative safety of bacterial risk control strategies for platelet components: a simulation study . Transfusion . 2020;60(8):1723–31.
Pagano MB, et al. Current advances in transfusion medicine: a 2019 review of selected topics from the AABB Clinical Transfusion Medicine Committee . Transfusion . 2020;60(7):1614–23.
White SK, et al. Bacterial contamination rate of platelet components by primary culture: A systematic review and meta-analysis . Transfusion . 2020;60(5):986–96.
Lim MY, et al. Things we do for no reason: routinely prescribing transfusion premedication to prevent acute transfusion reactions . Journal of Hospital Medicine . 2020;15(11):684–6.
Gavva C, et al. Response to random apheresis platelets versus HLA-selected platelets versus pooled platelets in HLA-sensitized patients . Transfusion . 2019;59(7):2276–81.
Metcalf RA, et al. The association of inpatient blood utilization and diagnosis related group weight: implications for risk-adjusted benchmarking . Transfusion . 2019;59(7):2316–23.
Pagano MB, et al. Evaluating safety and cost-effectiveness of platelets stored in additive solution (PAS-F) as a hemolysis risk mitigation strategy . Transfusion . 59 (4):1246–51.
Metcalf RA, et al. Severe hemolysis following extracorporeal right ventricular assist device placement . Transfusion . 2019;59(4): 1178–9.
Murphy C, et al. Transfusion associated chest pain . Transfusion . 2019;59(2):463–9.
Metcalf RA, et al. Severe ABO hemolytic disease of the newborn requiring exchange transfusion . J Pediatr Hematol Oncol . 2019;41(8):632–4.