AACC Clinical Lab Expo 2012

Elaine Lyon, PhD
Medical Director, Genetics Division
Co-Medical Director, Pharmacogenomics
Co-Director, Clinical Molecular Genetics Fellowship Program

Analysis Approaches for the Clinical Exome
Tuesday, July 17, 10:00 a.m.

Clinical exome sequencing can identify candidate genes and mutations for diseases with a suspected genetic etiology but without a known cause. However, with its massive amounts of data, exome-scale sequencing poses unique challenges for clinical laboratories. This presentation will focus on the applications and interpretation of NGS in a clinical setting and will provide approaches for data analysis. Selecting appropriate family members and filtering data to increase the likelihood of finding the causative variant will also be discussed.

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Mary Bronner, MD
Director, Anatomic Pathology/Oncology Division

Molecular Testing in Gastrointestinal Polyposis Syndromes
Tuesday, July 17, 2:00 p.m.

This presentation will discuss the clinical, pathologic, and molecular diagnostic features of the seven known human gastrointestinal polyposis syndromes, including familial adenomatous polyposis, juvenile polyposis, Peutz-Jeghers polyposis, the PTEN harmartoma syndromes, ganglioneuromatosis, and tuberous sclerosis.

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Joely A. Straseski, PhD, MS, MT(ASCP), DABCC
Medical Director, Endocrinology
Co-Medical Director, Core Laboratory

Counting Eggs Before They Hatch: Utility of Anti-Mullerian Hormone as a Marker of Ovarian Reserve
Wednesday, July 18, 10:00 a.m.

Anti-Mullerian hormone (AMH), a product of growing ovarian follicles, is one of the newest markers of ovarian reserve and has received high praise for its correlation with antral follicle counts, stability across the menstrual cycle, and minimal variation over time. AMH may be a useful piece of the puzzle when determining a patient’s responsiveness to in vitro fertilization and other fertilization therapies.

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Gwen McMillin, PhD
Medical Director, Toxicology and Trace Elements Laboratories
Co-Medical Director, Pharmacogenetics

Potential Roles of the Clinical Laboratory in the Support of Pain Management Patients
Wednesday, July 18, 2:00 p.m.

Drug testing for chronic pain management patients differs from other drug testing applications. This presentation will review the routine drug testing needs of this population, with emphasis on opportunities for the clinical laboratory. Models for urine drug testing algorithms and cost-conscious test utilization will be proposed.

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Event Details

Genetics

ARUP Laboratories’ Genetics Division offers biochemical genetics, cytogenetics, molecular genetics, and maternal serum screening testing. Our eight lab-based genetic counselors are available for consultation with clinicians on test orders and results interpretation.

Our full-service genetics laboratory menu includes:

• Carrier screening for cystic fibrosis, Ashkenazi Jewish disorders, and fragile X syndrome
• Chromosome analysis on multiple samples types, including amniotic fluid, chorionic villus sampling, and products of conception
• Fetal genomic microarray

Pain Management

Periodic drug testing is an excellent tool for evaluating adherence with prescribed medications. Such testing is particularly useful when opioids, or other controlled substances, are prescribed and has become a routine practice for specialized pain management clinics. Periodic drug testing can also detect use of non-prescribed medications and illicit drugs.

Our full-service pain management laboratory menu includes:

• Multi-drug screens: drugs of abuse, urine, serum/plasma, and time of flight
• Opiates
• Pain management support tests, quantitative: opioids, benzodiazepines, and THC

Cost Containment and Decision Support

High-cost care does not equal high-quality care. ARUP’s financial-management tools offer real solutions for your laboratory needs. With an integrated focus on reducing costs and enhancing efficiency, our integrated health-diagnostics tools help you increase revenue, manage send-outs, decrease unnecessary spending, and promote more effective patient care. We work with you to streamline and improve processes, so you can be ready for next-era care delivery.

As healthcare delivery moves forward, you laboratory can play a vital role in driving clinical decisions and promoting evidence-based medicine. Position your lab to provide your clinicians with knowledge to promote better health processes, better individual patient care, and better population health.

• ARUP Insource Advantage^™–Analyze costs and volume data to manage send-out services; focus on high-volume, high-cost tests.
• ARUP ATOP^®–Reduce costs by identifying over-, under-, and misutilization of lab tests.
• ARUP Consult^®—Order the right test at the right time via point of care access to education information.