Gastrointestinal Pathology

Gastrointestinal Pathology provides comprehensive consultative expertise and services relating to disorders of the gastrointestinal tract, liver, and pancreas. A variety of specialized biomarkers and molecular tests are routinely available.

The focus of Gastrointestinal Pathology is molecular diagnostics of gastrointestinal tumors and inherited colorectal cancer, including mutational testing in colorectal cancer for determination of therapeutic response to EGFR inhibitors.

For information concerning consultation, please call (801) 581-2507. Consultations can be sent directly to:

Surgical Pathology Department
Huntsman Cancer Hospital
1950 Circle of Hope, RM N3105
Salt Lake City, UT 84112
Phone: (801) 581-2507 or (801) 584-5078
Fax: (801) 581-7035

Please include pertinent clinical history and surgical pathology report(s).
Test # Test Name Test Keywords Additional Information
Consultation, Dr. Rosai
2007228 5-Fluorouracil (5-FU) Toxicity and Chemotherapeutic Response, 5 Mutations 5-FU, 5-Fluorouracil Toxicity and Chemotherapeutic Response Panel, Pharmacogenetics (PGx), Colorectal Cancer
2003433 Pan Cytokeratin (AE1,3) by Immunohistochemistry Glucagonoma, Somatostatinoma, VIPoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Mesothelioma, Testicular Cancer, Tumor Markers, Synovial Sarcoma, Epithelial Sarcoma, Carcinoma, Adenocarcinoma, Tumor Markers, AE1,3 Stain and return service only
2003418 Alpha-1-Antichymotrypsin (A1ACT) by Immunohistochemistry Pancreatic Acinar Carcinoma, Alpha-1 Antitrypsin Deficiency, Tumor Markers Stain and return service only
2003436 Alpha-1-Fetoprotein (AFP) by Immunohistochemistry Testicular Germ Cell tumor, Ovarian Germ Cell Tumor, Brain Tumors, Tumor Markers Stain and return service only
2011890 Arginase 1 by Immunohistochemistry
2003454 Beta-Catenin-1 by Immunohistochemistry Solid-pseudopapillary Neoplasm of Pancreas, Desmoid-type Fibromatosis, Ovarian Cancer, Tumor Markers, Stain and return service only type Stain and return service only
2002498 BRAF codon 600 Mutation Detection by Pyrosequencing Melanoma, Colorectal cancer, Lynch Syndrome, HNPCC, Hereditary Nonpolyposis Colorectal Cancer, Gastrointestinal Adenocarcinoma, Papillary thyroid carcinoma
0051750 BRAF Codon 600 Mutation Detection with Reflex to MLH1 Promoter Methylation BRAF RFLX, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Lynch Syndrome, Tumor Markers
2013921 BRAF V600E Mutation Detection in Circulating Cell-Free DNA by Digital Droplet PCR
2008652 c-MET by Immunohistochemistry Stain and return service only
2003484 Caldesmon by Immunohistochemistry Gastrointestinal Stromal Tumors, GIST, endometrial, stromal, smooth muscle tumors, Tumor Markers Stain and return service only
2010757 Cancer Panel, Hereditary, Deletion/Duplication, 46 Genes CANCER DD, ALK, APC, BAP1, BMPR1A, CDH1, CDK4, CDKN1B, CDKN2A, EPCAM, FH, FLCN, MAX, MEN1, MET, MLH1, MSH2, MSH6, MUYTH, NF2, PHOX2B, PTEN, RB1, RET, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCB1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, Lynch syndrome, breast cancer, multiple endocrine neoplasia, melanoma, retinoblastoma, paraganglioma, Li-Fraumeni, familial adenomatous polyposis, Peutz-Jegher, HNPCC, inherited cancer, renal cancer, GI cancer, colorectal cancer
2012032 Cancer Panel, Hereditary, Sequencing and Deletion/Duplication, 47 Genes CANCERPAN, Lynch syndrome, breast cancer, multiple endocrine neoplasia, melanoma, retinoblastoma, paraganglioma, Li-Fraumeni, familial adenomatous polyposis, Peutz-Jegher, HNPCC, inherited cancer, renal cancer, GI cancer, colorectal cancer, NGS cancer panel
2003824 Carcinoembryonic Antigen, Monoclonal (CEA M) by Immunohistochemistry Mesothelioma, Ovarian Cancer, Colorectal Cancer, Tumor Markers, Cervical Cancer Stain and return service only
2003827 Carcinoembryonic Antigen, Polyclonal (CEA P) by Immunohistochemistry Hepatocellular Carcinoma, canallicular marker, Pancreatic Cancer, Ovarian Cancer, Lung Cancer, Colorectal Cancer, Tumor Markers Stain and return service only
2003806 CD117 (c-Kit) by Immunohistochemistry Gastrointestinal Stromal Tumors (GIST), Lung Cancer, Breast Cancer, Melanoma, Mast Cell Disease, Germ Cell Tumor of Testes and Ovary, Brain Tumors, Myelodysplastic Syndromes, Acute Myeloid Leukemia, (AML), Myeloproliferative Neoplasms (MPN), Tumor Markers Additional Technical Information
Stain and return service only
2003556 CD34, QBEnd/10 by Immunohistochemistry B-ALL, T-ALL, Acute myelogenous leukemia, MDS, Tumor Markers Stain and return service only
2003821 CDX2 by Immunohistochemistry Intestinal-type sinonasal adenocarcinoma, Colorectal Cancer, Tumor Markers, Lung Cancer Stain and return service only
2003830 Chromogranin A by Immunohistochemistry Neuroendocrine Tumors (NET), Carcinoid Tumors, Medullary Thyroid Cancer, Tumor Markers, Paraganglioma, Carotid body tumor, Olfactory neuroblastoma, pituitary adenomas, islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas, Merkel cell tumors, and carcinoids Stain and return service only
0093399 Circulating Tumor Cell Count Colorectal Cancer, Tumor Markers, mestastatic colorectal carcinoma, mestastic breast cancer, mestastic prostate cancer, prognostic Additional Technical Information
2011616 Colon Cancer Gene Panel, Somatic
2010229 Cytogenomic Molecular Inversion Probe Array, Copy Number and Heterozygosity Assessment - Formalin-Fixed Paraffin-Embedded (FFPE) Tissue FFPE ARRAY, array CGH; aCGH; Array Comparative Genomic Hybridization; Chromosomal Microarray; CMA;  CGH; Microarray; Single-nucleotide-polymorphism (SNP) array; Whole Genome Array; tumor; oncology, formalin-fixed, paraffin-embedded, FFPE; tissue
2003848 Cytokeratin 20 (CK 20) by Immunohistochemistry Tumor Markers, Bladder Cancer, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Lung Cancer, Colorectal Cancer, Multiple Carcinomas , Merkel Cell, adenomas, gallbladder, bile duct, gastrointestinal adenocarcinoma, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, transitional cell carcinoma, Pancreatic carcinoma, cholangiocarcinoma, Mesothelioma Stain and return service only
2003854 Cytokeratin 7 (CK 7) by Immunohistochemistry Gastrinoma, Mesothelioma, Bladder Cancer, Ovarian Cancer, Lung Cancer, Tumor Markers, Multiple Carcinomas, Breast Cancer Stain and return service only
2003493 Cytokeratin 8,18 Low Molecular Weight (CAM 5.2) by Immunohistochemistry Carcinoid Tumors, Hepatocellular Carcinoma, Renal Cell, Rhabdoid tumors, Neuroendocrine, Pancreatic Cancer, Pheochromocytoma, Melanoma, Tumor Markers, Multiple Carcinomas, Colon Cancer, Gastrointestinal Cancer Stain and return service only
2000623 Cytology, Non-Gynecologic
2003863 Desmin by Immunohistochemistry Smooth Muscle, Reactive Mesothelial cells, leiomyosarcomas, myogenic sarcomas, rhabdomyosarcoma, PNET, neuroblastoma, GIST, gastrointestinal stromal tumor, Tumor Markers Stain and return service only
2012166 Dihydropyrimidine Dehydrogenase (DPYD) Genotyping, 3 Mutations DYPD 5-Fluorouracil toxicity 5-FU toxicity 5-FU toxicity 5FU toxicity Adrucil (DPYD) Genotyping, 3 Mutations Xeloda (capecitabine) (DPYD) Genotyping, 3 Mutations DPD Uftoral (tegafur/uracil) (DPYD) Genotyping, 3 Mutations
2010168 DOG1 by Immunohistochemistry
2013906 Epi proColon
2003872 Epithelial Membrane Antigen (EMA) by Immunohistochemistry Adenocarcinoma, anaplastic large cell lymphomas, epitheloid sarcomas, Pagets’ disease, plasmacytomas, Pancreatic tumors, Tumor Markers Stain and return service only
0049178 ERBB2 (HercepTest®) by Immunohistochemistry, Tissue with Reflex to FISH if 2+ Gastric, gastrointestinal cancer, tumor marker, pharmacogenetics, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, Pancreatic Cancer, Gastric Cancer, Barrett’s Esophagus Cancer, Gastroesophageal Junction Cancer
0049174 ERBB2 (HercepTest®) with Interpretation by Immunohistochemistry, Tissue Gastric, gastrointestinal cancer, tumor marker, pharmacogenetics, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, Pancreatic Cancer, Gastric Cancer, Barrett’s Esophagus Cancer, Gastroesophageal Junction Cancer
2003878 Factor XIIIa by Immunohistochemistry Hepatocellular Carcinoma Stain and return service only
2004863 Familial Adenomatous Polyposis (APC) Sequencing APC FGS, Colorectal Cancer, colon cancer, CRC, polyps, Familial Adenomatious Polyposis FAP, familial cancer
2004915 Familial Adenomatous Polyposis Panel: APC Sequencing, APC Deletion/Duplication, and MYH 2 Mutations FAP Panel, Familial Adenomatious Polyposis familial cancer, Colorectal Cancer, colon cancer, CRC, polyps, FAP, familial cancer
2001961 Familial Mutation, Targeted Sequencing SEQ FSM

The following genes are available:
ACADVL, ACADM, ACVRL1, APC, ASS1, ATP7A, BMPR1A, BMPR2, BTD, CCM1, CCM2, CCM3, CDKL5, CFTR, COL4A5, CYP1B1, ENG, F8, F9, FBN1, G6PD, GALT, GJB2; HBA1, HBA2, HBB, INSR, LMNA, MECP2,MEFV, MEN1, MLH1, MSH2; MSH6, MUTYH, MYH3, NF1, OTC, PLOD1, PMS2; PRSS1, PTEN, PTPN11, RASA1, RET, SDHB, SDHC, SDHD, SLC22A5, SLC25A13, SMAD4, SPRED1, SPINK1, SOS1, STK11, TACI, TGFBR1, TGFBR2, UBE3A, VHL, VWF

2003896 Gastrin by Immunohistochemistry Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Carcinoid Tumors, Tumor Markers Stain and return service only
2013449 Gastrointestinal Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 16 Genes GICAPAN, APC, BMPR1A, CDH1, EPCAM, MLH1, MSH2, MSH6, MUTYH, PTEN, SDHB, SDHC, SDHD, SMAD4, STK11, TP53, colon, colorectal, cancer, gastrointestinal, stomach, GI cancer, polyp, FAP, polyposis, diffuse gastric, Lynch, HNPCC, MAP, Juvenile Polyposis, Peutz-Jeghers, Li-Fraumeni APC, BMPR1A, CDH1, EPCAM, MLH1, MSH2, MSH6, MUTYH, PTEN, SDHB, SDHC, SDHD, SMAD4, STK11, TP53, diffuse gastric cancer, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP)
2002674 Gastrointestinal Stromal Tumor Mutation Gastrointestinal Stromal Tumors (GIST) Additional Technical Information
2011925 Glypican 3 by Immunohistochemistry
2003941 Helicobacter pylori by Immunohistochemistry Gastric adenocarcinoma, gastric B-cell lymphoma persistent dyspepsia;duodenal ulcer, gastric MALT, early gastric cancer, gastritis Stain and return service only
2003923 Hepatocyte Specific Antigen (HSA) by Immunohistochemistry Hepatocellular Carcinoma Stain and return service only
0051650 HNPCC/Lynch Syndrome (MLH1) Sequencing and Deletion/Duplication MLH1 FGA, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, MLH1, MSH2, MSH6, PMS2, mismatch repair, Muir-Torre, Turcot, Lynch
0051654 HNPCC/Lynch Syndrome (MSH2) Sequencing and Deletion/Duplication MSH2 FGA, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, MLH1, MSH2, MSH6, PMS2, mismatch repair, Muir-Torre, Turcot, Lynch Additional Technical Information
0051656 HNPCC/Lynch Syndrome (MSH6) Sequencing and Deletion/Duplication MSH6 FGA, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, MLH1, MSH2, MSH6, PMS2, mismatch repair, Muir-Torre, Turcot, Lynch Additional Technical Information
0051737 HNPCC/Lynch Syndrome (PMS2) Sequencing and Deletion/Duplication PMS2 FGA, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, MLH1, MSH2, MSH6, PMS2, mismatch repair, Muir-Torre, Turcot, Lynch Additional Technical Information
2001728 HNPCC/Lynch Syndrome Deletion/Duplication HNPCC DD, Hereditary Nonpolyposis Colorectal Cancer, Colorectal Cancer, MLH1, MSH2, MSH6, PMS2, mismatch repair, Muir-Torre, Turcot, Lynch Syndrome Additional Technical Information
2003920 Human Chorionic Gonadotropin (Beta-hCG) by Immunohistochemistry Trophoblastic, germ cell, lung, melanoma, gastrointestinal, ovarian, testicular cancer Stain and return service only
2004988 Juvenile Polyposis (BMPR1A) Sequencing BMPR1A FGS, JPS, SMAD4, Juvenile Polyposis
2004992 Juvenile Polyposis (BMPR1A) Sequencing and Deletion/Duplication BMPR1A FGA, JPS, SMAD4
2001976 Juvenile Polyposis (SMAD4) Deletion/Duplication SMAD4 DD, Hereditary Hemorrhagic Telangiectasia (HHT), JP/HHT, BMPR1A, JPS, Juvenile Polyposis
0051510 Juvenile Polyposis (SMAD4) Sequencing SMAD4 SEQ, Hereditary Hemorrhagic Telangiectasia (HHT), JP/HHT, BMPR1A, JPS, Myhre, Juvenile Polyposis
2001971 Juvenile Polyposis (SMAD4) Sequencing and Deletion/Duplication SMAD4 FGA, Hereditary Hemorrhagic Telangiectasia (HHT), JP/HHT, BMPR1A, JPS, Juvenile Polyposis
2004984 Juvenile Polyposis Syndrome (BMPR1A) Deletion/Duplication BMPR1A DD, JPS, SMAD4, Juvenile Polyposis
0040137 KIT (D816V) Mutation by PCR Mast Cell Disease, C-KIT, CKIT Additional Technical Information
2002437 KIT Mutations in AML by Fragment Analysis and Sequencing Acute Myeloid Leukemia (AML), C-KIT, CKIT Additional Technical Information
2002695 KIT Mutations, Melanoma Melanoma, Tumor Markers, C-KIT, CKIT Additional Technical Information
0040248 KRAS Mutation Detection Pharmacogenetics (PGx), Lung Cancer, Colorectal Cancer, Tumor Markers, CRC, colon, rectal Additional Technical Information
2001932 KRAS Mutation Detection with BRAF reflex Pharmacogenetics (PGx), Lung Cancer, Colorectal Cancer, Tumor Markers, CRC, colon, rectal Additional Technical Information
0051740 Microsatellite Instability (MSI), HNPCC/Lynch Syndrome, by PCR MSI PCR, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Lynch Syndrome, Tumor Markers, MSI, MLH1, MSH2, MSH6, PMS2, mismatch repair Additional Technical Information
0049302 Mismatch Repair by Immunohistochemistry MSI, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Tumor Markers, MLH1, MSH2, MSH6, PMS2, mismatch repair, IHC, Lynch Additional Technical Information
2002327 Mismatch Repair by Immunohistochemistry with Reflex to BRAF Codon 600 Mutation and MLH1 Promoter Methylation Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Tumor Markers, MSI, MLH1, MSH2, MSH6, PMS2, mismatch repair, IHC, Lynch
2005270 Mismatch Repair by Immunohistochemistry with Reflex to MLH1 Promoter Methylation MSI MLH1, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Tumor Markers, MLH1, MSH2, MSH6, PMS2, mismatch repair, IHC, Lynch Additional Technical Information
2002499 MLH1 Promoter Methylation, Paraffin MLH1PCR, Colorectal Cancer, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Tumor Markers Additional Technical Information
2004002 Muc-1 by Immunohistochemistry Glandular differentiation marker, Pancreatic, thyroid cancer, biliary, Salivary gland Stain and return service only
2004008 Muc-4 by Immunohistochemistry Colorectal Cancer, Tumor Markers, Pancreatic, thyroid, salivary gland, biliary Stain and return service only
2003999 Muc-5AC by Immunohistochemistry Glandular differentiation marker, Tumor Markers Pancreatic, cholangiocarcinoma, gastric Stain and return service only
2004911 MUTYH-Associated Polyposis (MUTYH) 2 Mutations MYH SEQ, Hereditary Colorectal Cancer, MAP, MUTH Associated Polyposis
2003123 NRAS Mutation Detection by Pyrosequencing Colorectal, melanoma, Hereditary Nonpolyposis Colorectal Cancer , HNPCC, Tumor Markers, CRC, colon, rectal Additional Technical Information
2004064 p16 by Immunohistochemistry Head and Neck Cancer, Cervical Cancer, Bladder Cancer, Ovarian Cancer, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Tumor Markers, Pancreatic Cancer, Melanoma, prognostic Stain and return service only
2004067 p21 (Waf1/Cip 1) by Immunohistochemistry Pancreatic Cancer, Melanoma, Bladder Cancer, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Tumor Markers Stain and return service only
2002012 Pancreatitis, (SPINK1) Sequencing SPINK1 FGS, Idiopathic pancreatitis, acute pancreatitis, N34S, PSTI, pancreatic secretory trypsin inhibitor
2008377 Peutz-Jeghers Syndrome (STK11) Deletion/Duplication STK11, STK11 DD, hamartomatous polyps, mucocutaneous hypergigmentation
2008394 Peutz-Jeghers Syndrome (STK11) Sequencing STK11, STK11 FGS, hamartomatous polyps, mucocutaneous hypergigmentation
2008398 Peutz-Jeghers Syndrome (STK11) Sequencing and Deletion/Duplication STK11, STK11 FGA, hamartomatous polyps, mucocutaneous hypergigmentation
2004510 PIK3CA Mutation Detection Tumor Markers, Breast Cancer, Colorectal Cancer, Lung Cancer, Gastrointestinal Cancer, Pancreatic Cancer Additional Technical Information
2004091 Protein Gene Product (PGP) 9.5 by Immunohistochemistry Glucagonoma, Somatostatinoma, VIPoma, Ewing Sarcoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Carcinoid Tumors, Pancreatic Cancer, Pheochromocytoma, Tumor Markers, neuronal neoplasis Stain and return service only
2004115 PTEN by Immunohistochemistry Prostate Cancer, prostate epithelium, breast, ductal epithelium, gastric mucosa, glial cells Stain and return service only
2007031 PTEN with Interpretation by Immunohistochemistry
2006948 SDHB with Interpretation by Immunohistochemistry
2007991 Solid Tumor Mutation Panel by Next Generation Sequencing Additional Technical Information
0051332 UDP Glucuronosyltransferase 1A1 (UGT1A1) Genotyping UGT1A1, Irinotecan, Pharmacogenetics (PGx), Colorectal Cancer