Breast Pathology

Breast Pathology is a key component in the early diagnosis and treatment of breast disease. ARUP provides pathologists, referring physicians, and patients with expert consultative diagnoses, as well as guidance on appropriate management. We have extensive experience interpreting all types of breast specimens, including surgical pathology specimens, core needle biopsies, and fine needle aspirations of cases ranging from early borderline disease to the most advanced stage cancer. In addition to consultative service, a variety of specialized molecular tests are routinely available.

The Immunohistochemistry Laboratory provides analysis of ER/PR expression, ERBB2 (HER2-neu) overexpression, proliferation, and other markers. This laboratory is an NSABP-approved laboratory for the testing of breast markers.

For information concerning consultation, please call (801) 581-2507. Consultations can be sent directly to:

Surgical Pathology Department
Huntsman Cancer Hospital
1950 Circle of Hope, RM N3105
Salt Lake City, UT 84112
Phone: (801) 581-2507 or (801) 584-5078
Fax: (801) 581-7035

Please include pertinent clinical history and surgical pathology report(s).
Test # Test Name Test Keywords Additional Information
Consultation, Dr. Rosai
2003433 Pan Cytokeratin (AE1,3) by Immunohistochemistry Glucagonoma, Somatostatinoma, VIPoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Mesothelioma, Testicular Cancer, Tumor Markers, Synovial Sarcoma, Epithelial Sarcoma, Carcinoma, Adenocarcinoma, Tumor Markers, AE1,3 Stain and return service only
2003463 Anti-Human Epithelial Antigen, Ber-EP4 by Immunohistochemistry Mesothelioma, Lung Cancer, mammary Paget disease, lung adenocarcinomas, trichoepitheliomas, dermatofibromas, basal cell carcinoma, Lung cancer, mesothelioma Stain and return service only
2003472 Breast 2 (GCDFP-15) by Immunohistochemistry Tumor Markers, Mammary carcinoma, Extramammary Pagets disease Stain and return service only
2012026 Breast and Ovarian Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 20 Genes BOCAPAN, Breast Cancer, Tumor Markers, FISH, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MEN1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53
2011954 Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) Sequencing BRCA FGS, BRACA, HBOC
2011949 Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) Sequencing and Deletion/Duplication BRCA FGA, BRACA, HBOC
2003445 Breast Carcinoma b72.3 by Immunohistochemistry Mesothelioma, Lung Cancer, Tumor Markers, Adenocarcinoma, Breast carcinoma Stain and return service only
2010757 Cancer Panel, Hereditary, Deletion/Duplication, 46 Genes CANCER DD, ALK, APC, BAP1, BMPR1A, CDH1, CDK4, CDKN1B, CDKN2A, EPCAM, FH, FLCN, MAX, MEN1, MET, MLH1, MSH2, MSH6, MUYTH, NF2, PHOX2B, PTEN, RB1, RET, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCB1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, Lynch syndrome, breast cancer, multiple endocrine neoplasia, melanoma, retinoblastoma, paraganglioma, Li-Fraumeni, familial adenomatous polyposis, Peutz-Jegher, HNPCC, inherited cancer, renal cancer, GI cancer, colorectal cancer
2012032 Cancer Panel, Hereditary, Sequencing and Deletion/Duplication, 47 Genes CANCERPAN, Lynch syndrome, breast cancer, multiple endocrine neoplasia, melanoma, retinoblastoma, paraganglioma, Li-Fraumeni, familial adenomatous polyposis, Peutz-Jegher, HNPCC, inherited cancer, renal cancer, GI cancer, colorectal cancer, NGS cancer panel
2003824 Carcinoembryonic Antigen, Monoclonal (CEA M) by Immunohistochemistry Mesothelioma, Ovarian Cancer, Colorectal Cancer, Tumor Markers, Cervical Cancer Stain and return service only
0093399 Circulating Tumor Cell Count Colorectal Cancer, Tumor Markers, mestastatic colorectal carcinoma, mestastic breast cancer, mestastic prostate cancer, prognostic Additional Technical Information
2012769 Cytochrome P450 2C19, CYP2C19 - 9 Variants CYP2C19, Pharmacogenetics (PGx), Schizophrenia, Breast Cancer, breast biomarkers
0051232 Cytochrome P450 2D6 (CYP2D6) 14 Mutations and Gene Duplication CYP 2D6, Tamoxifen, Pharmacogenetics (PGx), Schizophrenia, Breast Cancer, breast biomarkers
2000623 Cytology, Non-Gynecologic
0095155 DNA Content/Cell Cycle Analysis, Miscellaneous
2003869 E-Cadherin by Immunohistochemistry Mesothelioma, Breast Cancer, Tumor Markers Stain and return service only
2003872 Epithelial Membrane Antigen (EMA) by Immunohistochemistry Adenocarcinoma, anaplastic large cell lymphomas, epitheloid sarcomas, Pagets’ disease, plasmacytomas, Pancreatic tumors, Tumor Markers Stain and return service only
2008603 ERBB2 (HER-2/neu) Gene Amplification by FISH, Tissue HER2FISH, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, pathvision, pathvysion
2007332 ERBB2 (HER2)(HercepTest) by Immunohistochemistry HERCEP IHC
2007785 ERBB2 (HER2/neu) (HercepTest) by Immunohistochemistry, Tissue with Reflex to Dual ISH if 2+
0049390 ERBB2 (HER-2/neu) Gene Amplification by PCR Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu Additional Technical Information
0049178 ERBB2 (HercepTest®) by Immunohistochemistry, Tissue with Reflex to FISH if 2+ Gastric, gastrointestinal cancer, tumor marker, pharmacogenetics, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, Pancreatic Cancer, Gastric Cancer, Barrett’s Esophagus Cancer, Gastroesophageal Junction Cancer
0049174 ERBB2 (HercepTest®) with Interpretation by Immunohistochemistry, Tissue Gastric, gastrointestinal cancer, tumor marker, pharmacogenetics, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, Pancreatic Cancer, Gastric Cancer, Barrett’s Esophagus Cancer, Gastroesophageal Junction Cancer
2004516 Estrogen Receptor (ER) by Immunohistochemistry Ovarian Cancer, Breast Cancer, Tumor Markers Stain and return service only
0049210 Estrogen/Progesterone Receptor with Interpretation by Immunohistochemistry Breast Cancer, Tumor Markers
2003978 Keratin 903 (K903) High Molecular Weight by Immunohistochemistry Mesothelioma, Bladder Cancer, Prostate Cancer, Breast Cancer Stain and return service only
2007182 Ki-67 with Interpretation by Immunohistochemistry
0049250 p53 with Interpretation by Immunohistochemistry Brain Tumors, Head and Neck Cancer, Chronic Lymphocytic Leukemia (CLL), Bladder Cancer, Ovarian Cancer, Hereditary Nonpolyposis Colorectal Cancer (HNPCC), Breast Cancer, Colorectal Cancer, Tumor Markers, Tumor suppressor protein, prognostic indicator, Non-small cell lung cancer, lung cancer
2010787 PAX8 by Immunohistochemistry PAX8, combined with organ system-specific markers, can collectively serve as a very useful panel to determine the primary site of micropapillary ovarian carcinomas from invasive carcinomas arising from bladder, lung, and breast.
2004510 PIK3CA Mutation Detection Tumor Markers, Breast Cancer, Colorectal Cancer, Lung Cancer, Gastrointestinal Cancer, Pancreatic Cancer Additional Technical Information
2004525 Progesterone Receptor (PR) by Immunohistochemistry Tumor Markers, Breast Cancer, Ovarian Cancer Stain and return service only
2010248 Prosigna Breast Cancer Prognostic Gene Signature pam50, pam 50, PAM50, PAM 50, PAM-50
2004115 PTEN by Immunohistochemistry Prostate Cancer, prostate epithelium, breast, ductal epithelium, gastric mucosa, glial cells Stain and return service only
2002726 PTEN-Related Disorders Deletion/Duplication PTENDELDUP, PTEN hamartoma tumor, PHTS, Cowden, CS, Bannayan-Riley-Ruvalcaba, BRRS, Proteus, PS, Proteus-like, PSL, macrocephaly, autism
2002722 PTEN-Related Disorders Sequencing PTEN FGS, PTEN hamartoma tumor, PHTS, Cowden, CS, Bannayan-Riley-Ruvalcaba, BRRS, Proteus, PS, Proteus-like, PSL, macrocephaly, autism
2002470 PTEN-Related Disorders Sequencing and Deletion/Duplication PTEN FGA, PTEN hamartoma tumor, PHTS, Cowden, CS, Bannayan-Riley-Ruvalcaba, BRRS, Proteus, PS, Proteus-like, PSL, macrocephaly, autism
2007991 Solid Tumor Mutation Panel by Next Generation Sequencing Additional Technical Information